TV 켜놓고 자면 뇌 손상올 수 있어 SOME HARMFUL EFFECTS OF LIGHT AT NIGHT CAN BE REVERSED, STUDY FINDS

뇌 해마 세포 감소 

우울증 위험도

source fourpins.com

edited by kcontents 

케이콘텐츠 편집

TV나 컴퓨터를 켜 놓은 채 잠들면 희미한 불빛이 뇌에 영향을 미쳐 우울증 발병 위험이 높아지는 것으로 나타났다.  미국 오하이오 주립대학교 신경과학과 연구팀은 햄스터를 16시간 동안 햇빛 아래 있도록 했다. 이후 두 그룹으로 나눠 한 그룹은 밤에 8시간동안 완전히 어두운 곳에 뒀다. 다른 그룹은 밤 8시간 동안 TV 화면과 비슷한 희미한 불빛에 계속 있게 했다.  연구자들은 8주 후 햄스터들에게 우울증 증상이 나타나는지 조사했다. 사람의 경우 평소 좋아하던 일을 갑자기 하지 않으면 우울증에 걸린 것으로 보는데 햄스터에게도 같은 원리를 적용했다.  햄스터들이 평소 좋아하는 설탕물을 더 마시는지 살펴보기 위해 수돗물과 설탕물을 함께 놓고 두 그룹 모두 마시도록 했다. 그 결과, TV 화면과 같은 밝기로 희미한 불빛에 계속 놓인 햄스터는 수돗물과 설탕물을 반반씩 마셨다.  이들은 수돗물과 설탕물 중 어떤 것을 더 좋아하는지 구별할 수 없었다. 연구팀은 “희미한 불빛에 계속 놓인 햄스터들은 설탕물을 먹어도 특별히 즐거움을 느끼지 않는다는 것을 알 수 있다”며 “이는 우울증과 맥락이 같다”고 말했다.  밤새 희미한 불빛에 노출된 햄스터들은 뇌의 해마 돌기 부분에 손상이 나타났다. 뇌의 해마돌기 세포가 줄어든 것이다. 연구팀은 “사람의 뇌도 감정을 조절하는 편도체 옆의 해마는 우울증과 관계가 있다”며 “해마돌기가 작은 사람은 극심한 우울증에 시달린다”고 말했다.  연구팀은 “이번 연구결과로 야간 근무를 많이 하는 사람들이나 밤에 불을 켜 놓고 자는 사람들 사이에 우울증 등 기분장애가 늘어나는 현상을 설명할 수 있다”고 말했다. 이런 내용은 미국 과학 논문 소개 사이트 유레칼러트 등에 실렸다.  코메디닷컴 권순일 기자 (kstt77@kormedi.com)

 

Chronic exposure to dim light at night can lead to depressive symptoms in rodents - but these negative effects can be reversed simply by returning to a standard light-dark cycle, a new study suggests.

While hamsters exposed to light at night for four weeks showed evidence of depressive symptoms, those symptoms essentially disappeared after about two weeks if they returned to normal lighting conditions.

Even changes in the brain that occurred after hamsters lived with chronic light at night reversed themselves after returning to a more normal light cycle.

These findings add to the growing evidence that suggest chronic exposure to artificial light at night may play some role in the rising rates of depression in humans during the past 50 years, said Tracy Bedrosian, lead author of the study and doctoral student in neuroscience at Ohio State University.

“The results we found in hamsters are consistent with what we know about depression in humans,” Bedrosian said.

But the new study, published online in the journal Molecular Psychiatry, also offers some hope.

“The good news is that people who stay up late in front of the television and computer may be able to undo some of the harmful effects just by going back to a regular light-dark cycle and minimizing their exposure to artificial light at night,” Bedrosian said. “That’s what the results we found in hamsters would suggest.”

Bedrosian conducted the study with Ohio State colleagues Randy Nelson, professor of neuroscience and psychology, and Zachary Weil, research assistant professor in neuroscience.

This study is the latest in a series out of Nelson’s lab that have linked chronic exposure to light at night to depression and obesity in animal models.

The new study found that one particular protein found in the brain of hamsters - and humans - may play a key role in how light at night leads to depression.

They found that blocking effects of that protein, called tumor necrosis factor, prevented the development of depressive-like symptoms in hamsters even when they were exposed to light at night.

The study involved two experiments using female Siberian hamsters, which had their ovaries removed to ensure that hormones produced in the ovary would not interfere with the results.

In the first experiment, half of the hamsters spent eight weeks in a standard light-dark cycle of 16 hours of light (150 lux) and 8 hours of total darkness each day. The other half spent the first four weeks with 16 hours of normal daylight (150 lux) and 8 hours of dim light - 5 lux, or the equivalent of having a television on in a darkened room.

Then, these hamsters were moved back to a standard light cycle for either one week, two weeks or four weeks before testing began.

They were then given a variety of behavior tests. Results showed that hamsters exposed to chronic dim light at night showed less total activity during their active period each day when compared to those in standard lighting conditions.

Those hamsters exposed to dim light also showed greater depressive symptoms than did the others - such as less interest in drinking sugar water that they usually enjoy.

But within two weeks of returning to a standard light cycle, hamsters exposed to dim night light showed no more depressive-like symptoms than did hamsters that always had standard lighting. In addition, they returned to normal activity levels.

After the behavioral testing, the hamsters were sacrificed and the researchers studied a part of their brains called the hippocampus, which plays a key role in depressive disorders. Findings showed that hamsters exposed to dim light showed a variety of changes associated with depression.

Most importantly, hamsters that lived in dim light showed increased expression of the gene that produces tumor necrosis factor. TNF is one of a large family of proteins called cytokines - chemical messengers that are mobilized when the body is injured or has an infection. These cytokines cause inflammation in their effort to repair an injured or infected area of the body. However, this inflammation can be damaging when it is constant, as happens in hamsters exposed to dim light at night.

“Researchers have found a strong association in people between chronic inflammation and depression,” said Nelson, who is a member of Ohio State’s Institute for Behavioral Medicine Research.

“That’s why it is very significant that we found this relationship between dim light at night and increased expression of TNF.”

“The good news is that people who stay up late in front of the television and computer may be able to undo some of the harmful effects.”

In addition, results showed that hamsters that lived in dim light had a significantly reduced density of dendritic spines - hairlike growths on brain cells which are used to send chemical messages from one cell to another.

Changes such as this have been linked to depression, Bedrosian said.

However, hamsters that were returned to a standard light-dark cycle after four weeks of dim light at night saw their TNF levels and even their density of dendritic spines return essentially to normal.

“Changes in dendritic spines can happen very rapidly in response to environmental factors,” Bedrosian said.

In a second experiment, the researchers tested just how important TNF might be in causing the negative effects seen in hamsters exposed to light at night. In this experiment, some hamsters were given a drug called XPro1595, which is a TNF inhibitor - meaning that it negates the effects of some forms of TNF in the brain.

Results showed that hamsters exposed to dim light at night did not show any more depressive-like symptoms than standard-light hamsters if they were given XPro1595. However, the drug did not seem to prevent the reduction of dendritic spine density in hamsters exposed to dim light.

These results provide further evidence of the role TNF may play in the depressive symptoms seen in hamsters exposed to dim light. But the fact that XPro1595 did not affect dendritic spine density means that more needs to be learned about exactly how TNF works, Nelson said.

The study was supported by grants from the National Science Foundation and the U.S. Department of Defense. The XPro1595 used in the study was provided by Xencor, Inc.

http://researchnews.osu.edu/archive/landepress.htm

케이콘텐츠 

kcontents

"from past to future"

데일리건설뉴스 construction news

콘페이퍼 conpaper