Nobel Prize for chemistry awarded to 3 scientists for DNA repair studies 노벨 화학상 린달, 모드리치, 산카르 3명 DNA 연구로 수상

Nobel Prize for chemistry awarded to 3 scientists for DNA repair studies


스웨덴의 토머스 린달(77), 미국의 폴 모드리치(69), 터키계 미국인 아지즈 산카르(69)

source edition.cnn.com

edited by kcontents 

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   2015년 노벨 화학상은 스웨덴의 토머스 린달(77)과 미국의 폴 모드리치(69), 터키계 미국인 아지즈 산카르(69) 등 3명이 공동수상했다고 스웨덴 왕립과학원 노벨위원회가 7일(현지시간) 발표했다.


스웨덴 왕립과학원 노벨위원회는 이날 이들 3명이 DNA 복구 매커니즘 연구로 화학상을 수상하게 됐다고 밝혔다.


노벨위원회는 이들의 연구를 통해 살아 있는 세포가 어떻게 기능을 발휘하는지를 알 수 있게 됐다며 이들의 발견으로 무엇보다도 새로운 암 치료의 방법을 열 수 있게 됐다고 덧붙였다. 


린달은 이날 "놀랍다"면서 "종종 후보로는 올랐는데 매우 운이 좋고 선택된데 자부심을 느낀다" 고 수상소감을 밝혔다. 린달의 수상으로 스웨덴은 29번째 노벨상 수상자를 배출하는 국가가 됐다. 린달은 영국 프랜시스 크릭 연구소의명예교수이자 클레어 연구소 암연구소 명예소장으로 재직 중이며 모드리치는 미국 노스 캐롤라이나주 더햄의 듀크대학 의대 교수이자 하워드 휴즈 의학연구소 교수로 일하고 있다. 터키 이스탄불대에서 엔자임 연구로 박사학위를 받은 산카르 역시 현재 노스 캐롤라이나주 채플 힐의 노스 캐롤라이나 의대 교수로 재직 중이다. 


이들은 800만 스웨덴 크로나(약 96만 달러)의 상금을 나눠 갖게 되며 시상식은 12월10일 열린다..

뉴시스 출처 조선일보


By Holly Yan and Don Melvin, CNN
(CNN)—The 2015 Nobel Prize for chemistry has been jointly awarded to three scientists for their "mechanistic studies of DNA repair," the Royal Swedish Academy of Sciences announced Wednesday. 

Tomas Lindahl, Paul Modrich and Aziz Sancar won "for having mapped, at a molecular level, how cells repair damaged DNA and safeguard the genetic information."

"Their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatments," the academy said. 

The organization tweeted graphics explaining the scientists' work.

Lindahl, a Swedish scientist, showed that "DNA decays at a rate that ought to have made the development of life on Earth impossible," the academy said. 

"This insight led him to discover a molecular machinery, base excision repair, which constantly counteracts the collapse of our DNA."

Modrich, an American, showed how a cell corrects errors that occur when DNA is replicated during cell division.

"This mechanism, mismatch repair, reduces the error frequency during DNA replication by about a thousandfold," the academy said. 

"Congenital defects in mismatch repair are known, for example, to cause a hereditary variant of colon cancer."

Sancar, a U.S. and Turkish citizen, mapped nucleotide excision repair -- the mechanism that cells use to repair UV damage to DNA, the academy said. 

"People born with defects in this repair system will develop skin cancer if they are exposed to sunlight, it said. 

Last year, two Americans and a German won the chemistry prize for their work on optical microscopy, which opened up our understanding of molecules by allowing us to see how they work close up. 

The winners were Eric Betzig, Stefan W. Hell and William E. Moerner. 

Since 1901, the committee has handed out the Nobel Prize in chemistry 107 times. In certain years, mainly during World Wars I and II, no prize in chemistry was awarded.

The youngest recipient was Frederic Joliot, who won in 1935 at the age of 35. The oldest chemistry laureate was John B. Fenn, who was 85 when he received the prize in 2002.

Frederic Sanger was the only scientist to win the chemistry prize twice, for his work related to the structure of proteins and DNA.

There is a fine line between the science of chemistry and the fields of physics and biology. 

Famed scientist Marie Curie of France, for example, won Nobel honors for her work in radiophysics in 1903 and again in 1911 for discoveries in radiochemistry.

This week, Nobel prizes have already been awarded in medicine and physics. 

The committee also will announce prizes in literature, peace and economics in the coming days.

Swedish industrialist Alfred Nobel created the prizes in 1895 to honor work in physics, chemistry, literature and peace. The economics prize, established in 1968 as a memorial to Nobel, was first awarded in 1969.

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